Peromyscus maniculatus is a rodent native to North America. It is most commonly called the Deer mouse, although that name is common to most species of Peromyscus and is fairly widespread across the continent, with the major exception being the southeast United States and the far north.

Like other Peromyscus species, it is a carrier of emerging diseases such as hantaviruses and lyme disease.

It is closely related to Peromyscus leucopus, the White-footed mouse.